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Chronic inflammatory demyelinating polyradiculoneuropathy in children: II. Long‐term follow‐up, with comparison to adults
Author(s) -
Simmons Zachary,
Wald John J.,
Albers James W.
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199712)20:12<1569::aid-mus12>3.0.co;2-w
Subject(s) - polyradiculoneuropathy , medicine , term (time) , pediatrics , physical therapy , physical medicine and rehabilitation , guillain barre syndrome , physics , quantum mechanics
We previously reviewed the presentation, initial clinical course, and electrodiagnostic features of children with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We now report the long‐term follow‐up of 12 children with idiopathic CIDP, and compare these to 62 adults with idiopathic CIDP. Children often had more rapidly fluctuating courses than adults. A relapsing course was significantly more common in children than in adults. The recovery of children from each episode of deterioration was usually excellent, and better, on average, than in adults. Ventilatory support was never required for children with slowly evolving illness; only 2 children with a precipitous onset clinically resembling Guillain‐Barré syndrome required ventilatory support. Prednisone, plasma exchange, and intravenous immunoglobulin (IVIg) usually were effective in children. Multiple courses of IVIg could be given with continued efficacy. Treatment often could be discontinued in children with relapsing courses. The prognosis for children was excellent. Adults demonstrated a good, but more variable, outcome. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1569–1575, 1997