Premium
Acetazolamide reduces peripheral afferent transmission in humans
Author(s) -
Brechue W.F.,
Koceja D.M.,
Stager J.M.
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199712)20:12<1541::aid-mus9>3.0.co;2-8
Subject(s) - isometric exercise , h reflex , electromyography , tibial nerve , acetazolamide , achilles tendon , reflex , anesthesia , muscle spindle , medicine , motor unit , stretch reflex , nerve conduction velocity , peripheral , anatomy , chemistry , tendon , stimulation , physical medicine and rehabilitation , afferent
Carbonic anhydrase has been localized in skeletal muscle and nerve, thus, inhibition with acetazolamide (ACZ) may alter nerve and/or muscle function in healthy humans. ACZ (3 oral doses 14, 8, and 2 h prior to testing) reduced isometric force (37%) and peak to peak electromyographic (EMG) amplitude (1.38 mV to 0.83 mV), while increasing EMG latency associated with a unilateral Achilles tendon‐tap. Reflex recovery profiles, following a contralateral conditioning tap, were similar in both placebo and ACZ experiments. ACZ led to significant changes in H max /M max ratio (52.19/14.42 to 45.73/15.65) and H‐reflex latency (34.18 ± 2.54 ms to 35.24 ± 2.74 ms). Motor nerve conduction velocity and maximal voluntary isometric torque (knee extensors) were unaltered by ACZ. These data suggest that inhibition of the tendon‐tap reflex and associated isometric force, following ACZ, is related to impairment of synaptic integrity between Ia fibers of the muscle spindle and the alpha motor neuron and not impairment of the muscle spindle or force‐generating capacity. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1541–1548, 1997