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Partial transformation from fast to slow muscle fibers induced by deafferentation of capsaicin‐sensitive muscle afferents
Author(s) -
Brunetti Orazio,
Barazzoni Anna M.,
Della Torre Giovannella,
Clavenzani Paolo,
Pettorossi Vito E.,
Bortolami Ruggero
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199711)20:11<1404::aid-mus8>3.0.co;2-e
Subject(s) - capsaicin , muscle spindle , chemistry , transformation (genetics) , neuroscience , anatomy , medicine , biology , receptor , afferent , gene , biochemistry
Mechanical and histochemical characteristics of the lateral gastrocnemius (LG) muscle of the rat were examined 21 days after capsaicin injection into the LG muscle. The capsaicin caused a decrease in generation rate of twitch and tetanic tension and an increase in fatigue resistance of LG muscle. The histochemical muscle fiber profile evaluated by myosin adenosine triphosphatase and reduced nicotinamide adenine dinucleotide tetrazolium reductase methods showed an increase of type I and IIC fibers and a decrease of the type IIB in whole muscle, and a decrease of the IIA, IIX fibers in the red part accompanied by their increase in the white part. Therefore the capsaicin treatment, which selectively eliminated fibers belonging to the III and IV groups of muscle afferents, induced muscle fiber transformation from fast contracting fatiguing fibers to slowly contracting nonfatiguing ones. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1404–1413, 1997