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Vacuolar myopathies in adults with myalgias: Value of paraspinal muscle investigation
Author(s) -
Petrella J. Terry,
Giuliani Michael J.,
Lacomis David
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199710)20:10<1321::aid-mus18>3.0.co;2-5
Subject(s) - myopathy , medicine , creatine kinase , weakness , histopathology , muscle weakness , pathology , glycogen phosphorylase , myalgia , anatomy , glycogen
We evaluated 4 women with chronic fatigue and myalgias. Two had proximal weakness. All had elevated serum creatine kinase levels, but none was diagnosed with myopathy until electrodiagnostic studies revealed myotonic or complex repetitive discharges predominantly in paraspinal muscles. Histopathology of paraspinal muscles revealed vacuolar myopathies with glycogen storage; biochemical assays revealed phosphorylase deficiency in 1. Since vacuolar myopathies may affect paraspinal muscles more than limb muscles, electromyographic and histopathologic studies of paraspinal muscles may be required for diagnosis. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1321–1323, 1997