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Corticosteroid effects in skeletal muscle: Gene induction/receptor autoregulation
Author(s) -
McKay Lorraine I.,
DuBois Debra C.,
Sun YuNien,
Almon Richard R.,
Jusko William J.
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199710)20:10<1318::aid-mus17>3.0.co;2-z
Subject(s) - autoregulation , skeletal muscle , endocrinology , medicine , gene , receptor , biology , neuroscience , genetics , blood pressure
Common side effects of corticosteroid therapy include muscle weakness and atrophy, which are in part mediated by the induction of the enzyme glutamine synthetase. In addition, corticosteroids autoregulate their own receptor, thereby modulating tissue sensitivity to the hormone. The data in this report demonstrate that these gene‐mediated effects are evident in muscle after short‐term administration. Determination of molecular response dynamics could be useful in the design of future treatment regimens. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1318–1320, 1997