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Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy
Author(s) -
Rotta Francisco T.,
Bradley Walter G.
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199708)20:8<1035::aid-mus16>3.0.co;2-u
Subject(s) - medicine , chemotherapy , polyneuropathy , chlorambucil , radiation therapy , peripheral neuropathy , surgery , multiple myeloma , cyclophosphamide , diabetes mellitus , endocrinology
We describe a patient with a 3 year history of progressive polyneuropathy that rendered him severely quadriparetic and bedridden. Work up revealed an IgG lambda monoclonal spike and multifocal osteosclerotic myeloma. Remarkable improvement followed combined treatment with surgical excision, radiation therapy, and chemotherapy using chlorambucil, danazol, and hydrocortisone. Hence, we believe that aggressive local therapy associated with systemic chemotherapy should be considered in severely affected patients with multifocal osteosclerotic myeloma and peripheral neuropathy. © 1997 John Wiley and Sons, Inc.