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The effect of duration of muscle denervation on functional recovery in the rat model
Author(s) -
Kobayashi Jun,
Mackin Susan E.,
Watanabe Osamu,
Ball Douglas J.,
Ming Gu Xiao,
Hunter Daniel A.,
Kuzon William M.
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199707)20:7<858::aid-mus10>3.0.co;2-o
Subject(s) - denervation , tibial nerve , medicine , hindlimb , anatomy , motor function , anesthesia , muscle mass , physical medicine and rehabilitation , stimulation
The effect of long‐term denervation on neuromuscular recovery was studied in a rat hind limb model. The posterior tibial nerve was transected and repaired immediately or after denervation periods of 2 weeks, or 1, 3, 6, 9, or 12 months. Six months following reconstruction excellent axonal regeneration was seen across all nerve repairs irrespective of periods of denervation. However, there was a precipitous and profound decrease in the recovery of both muscle mass and integrated motor function if the reconstruction was delayed for longer than 1 month. Rather than a progressive change proportional to the length of the denervation period, significant, more discrete changes occurred sometime after 1 month of denervation that precluded a full recovery of muscle mass. Integrated motor function quantified using walking track analysis was impaired even after immediate nerve repair. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 858–866, 1997