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Stimulated single‐fiber electromyography in Lambert‐Eaton myasthenic syndrome before and after 3,4‐diaminopyridine
Author(s) -
Sadeh Menachem,
River Yaron,
Argov Zohar
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199706)20:6<735::aid-mus11>3.0.co;2-t
Subject(s) - lambert eaton myasthenic syndrome , electromyography , medicine , repetitive nerve stimulation , jitter , neuromuscular transmission , myasthenia gravis , physical medicine and rehabilitation , electronic engineering , engineering
A patient with LEMS unrelated to cancer was studied by stimulated single‐fiber electromyography (SFEMG) before and 3 months after the onset of therapy with 3,4‐diaminopyridine. All end‐plates showed a progressive reduction in blockings and jitter with the increase in stimulation rate. Treatment significantly corrected this feature, but the overall pattern of frequency‐improved jitter remained. Such widespread finding is rare but diagnostic for Lambert‐Eaton myasthenic syndrome. Stimulated SFEMG can be used to monitor therapy in such patients. © 1997 John Wiley & Sons, Inc. Muscle Nerve, 20, 735–739, 1997.