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Expression of Fas antigen is not associated with apoptosis in human myopathies
Author(s) -
Inukai Akira,
Kobayashi Yasushi,
Ito Keita,
Doyu Manabu,
Takano Akemi,
Honda Hitoshi,
Sobue Gen
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199706)20:6<702::aid-mus7>3.0.co;2-c
Subject(s) - fas ligand , apoptosis , antigen , skeletal muscle , biology , dna fragmentation , myocyte , messenger rna , microbiology and biotechnology , immunology , pathology , endocrinology , programmed cell death , gene , medicine , biochemistry
To determine whether the Fas‐Fas‐ligand mediated apoptosis occurs in the pathologic process of human muscle diseases, we examined the expression of Fas antigen, Fas‐ligand messenger RNA, and chromosomal DNA fragmentation in the muscle cells of patients with a variety of human muscle disorders. The present study demonstrated that the Fas antigen of a whole molecule was expressed on the muscle fibers of patients with muscle wasting diseases. However, the apoptotic process did not occur in the muscle cells, and there was no evidence of Fas‐ligand synthesis in the diseased muscle tissue. Our data suggest that the expression of Fas antigen on fibers in diseased muscle is related to unknown biological functions other than “apoptosis” in the process of muscle fiber injury. © 1997 John Wiley & Sons, Inc. Muscle Nerve, 20, 702–709, 1997.