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Nonsystemic vasculitic mononeuropathy multiplex, cryoglobulinemia, and hepatitis C
Author(s) -
David William S.,
Peine Craig,
Schlesinger Peter,
Smith Stephen A.
Publication year - 1996
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199612)19:12<1596::aid-mus9>3.0.co;2-5
Subject(s) - medicine , cryoglobulinemia , mononeuropathy , mononeuritis multiplex , nerve biopsy , prednisone , vasculitis , hepatitis c , differential diagnosis , polyneuropathy , pathology , hepatitis , gastroenterology , dermatology , immunology , hepatitis c virus , peripheral neuropathy , endocrinology , diabetes mellitus , virus , disease
A 39‐year‐old man developed sequential acute mononeuropathies involving both median, both ulnar, and the right radial and left peroneal nerves. Electrophysiology demonstrated an asymmetric sensorimotor axonal polyneuropathy; nerve biopsy confirmed a vasculitis. Laboratory evaluation revealed a mixed cryoglobulinemia and active hepatitis C infection. The patient stabilized with prednisone/cyclophosphamide/interferon‐α. Hepatitis C should be considered in the differential diagnosis of mononeuropathy multiplex. Accurate diagnosis is important, as interferon‐α may prevent transition to chronic hepatitis/cirrhosis. © 1996 John Wiley & Sons Inc.