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Anti‐MAG and anti‐SGPG antibodies in neuropathy
Author(s) -
van den Berg Leonard H.,
Hays Arthur P.,
NobileOrazio Eduardo,
Kinsella Lawrence J.,
Manfredini Emanuela,
Corbo Massimo,
Rosoklija Gorazd,
Younger David S.,
Lovelace Robert E.,
Trojaborg Werner,
Lange Dale E.,
Goldstein Steven,
Delfiner Joel S.,
Sadiq Saud A.,
Sherman William H.,
Latov Norman
Publication year - 1996
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199605)19:5<637::aid-mus12>3.0.co;2-k
Subject(s) - antibody , medicine , peripheral neuropathy , immunology , diabetes mellitus , endocrinology
We compared the binding of human antibodies from patients with neuropathy to the myelin‐associated glycoprotein (MAG), to its cross‐reactive glycolipid sulfoglucuronyl paragloboside (SGPG), and to sections of peripheral nerve. Titers were correlated with the clinical presentation and results of electrophysiological and pathological studies. Most patients had a predominantly sensory or sensorimotor demyelinating neuropathy and highly elevated antibodies to both MAG and SGPG, but 2 had highly elevated antibodies to MAG alone, and 1 to SGPG alone. Two patients had predominantly motor neuropathy and highly elevated antibodies to SGPG which reacted with MAG by Western blot but not by enzyme‐linked immunosorbent assay. One patient had amyotrophic lateral sclerosis and antibodies to SGPG but not to MAG. These studies indicate that the neuropathic syndrome associated with anti‐MAG or ‐SGPG antibodies are more heterogeneous than previously suspected, and that although most of the antibodies react with both MAG and SGPG, some may react with MAG or SGPG alone. © 1996 John Wiley & Sons, Inc.