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Reduced oxidative muscle metabolism in chronic fatigue syndrome
Author(s) -
McCully Kevin K.,
Natelson Benjamin H.,
Iotti Stefano,
Sisto Sueann,
Leigh John S.
Publication year - 1996
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199605)19:5<621::aid-mus10>3.0.co;2-q
Subject(s) - phosphocreatine , medicine , oxidative metabolism , endocrinology , metabolism , oxidative phosphorylation , chronic fatigue syndrome , oxidative stress , muscle fatigue , chemistry , energy metabolism , biochemistry , electromyography , psychiatry
The purpose of this study was to determine if chronic fatigue syndrome (CSF) is characterized by abnormalities in oxidative muscle metabolism. Patients with CFS according to Centers for Disease Control (CDC) criteria ( n = 22) were compared to normal sedentary subjects ( n = 15). CFS patients were also tested before and 2 days after a maximal treadmill test. Muscle oxidative capacity was measured as the maximal rate of postexercise phosphocreatine (PCr) resynthesis using the ADP model (V max ) in the calf muscles using 31 P magnetic resonance spectroscopy. V max was significantly reduced in CFS patients (39.6 ± 2.8 mmol/L/min, mean ± SE) compared to controls (53.8 ± 2.8 mmol/L/min). Two days postexercise there was no change in resting inorganic phosphate (Pi)/PCr or V max in the CFS patients ( n = 14). In conclusion, oxidative metabolism is reduced in CFS patients compared to sedentary controls. In addition, a single bout of strenuous exercise did not cause a further reduction in oxidative metabolism, or alter resting Pi/PCr ratios. © 1996 John Wiley & Sons, Inc.