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“Sunbath polyneuritis”: Subacute axonal neuropathy in perazine‐treated patients after intense sun exposure
Author(s) -
Roelcke Ulrich,
Hornstein Christiane,
Hund Ernst,
Schmitt Horst P.,
Siess Rainer,
Kaltenmaier Matthias,
Fässler Jakob,
Meinck HansM.
Publication year - 1996
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199604)19:4<438::aid-mus2>3.0.co;2-d
Subject(s) - medicine , sural nerve , polyneuropathy , phenothiazine , lipid peroxidation , anesthesia , surgery , oxidative stress , psychiatry
This article aims at drawing attention to the peculiar association of intense exposure to sunlight and subacute development of sensory neuropathy which was seen in 7 psychiatric patients treated with the phenothiazine derivative, perazine. Three patients additionally developed bilateral VII nerve palsy. Symptoms followed a monophasic course with almost complete remission. Routine neurophysiology suggested axonal neuropathy confirmed by sural nerve biopsy in 1 patient. A toxic origin of neuropathy is supposed, possibly induced by phenothiazine photoproducts, which may cause cell damage via lipid peroxidation. © 1996 John Wiley & Sons, Inc.