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Hypertrophic neuritis due to chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): A postmortem pathological study
Author(s) -
Matsuda Masayuki,
Ikeda ShuIchi,
Sakurai Shunpei,
Nezu Aiyuki,
Yanagisawa Nobuo,
Inuzuka Takashi
Publication year - 1996
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199602)19:2<163::aid-mus6>3.0.co;2-c
Subject(s) - medicine , polyradiculoneuropathy , endoneurium , neuritis , pathological , pathology , chronic inflammatory demyelinating polyneuropathy , peripheral neuropathy , ataxia , anatomy , guillain barre syndrome , peripheral nerve , surgery , immunology , psychiatry , diabetes mellitus , endocrinology , antibody
A postmortem pathological study of a 65‐year‐old woman with hypertrophic neuritis associated with hand tremor and limb ataxia is described. There were many onion bulbs and loss of myelinated nerve fibers in the peripheral nerves, including the facial and subserosal visceral nerves. The hypertrophic neuritis was caused by chronic inflammatory demyelinating neuropathy (CIDP), in which interstitial amorphous substances in the endoneurium and onion bulb formation might contribute to nerve swelling. We speculate that visceral autonomic nerves as well as somatic peripheral nerves are involved in patients with a long clinical CIDP course and that peripheral nerve pathology in this disorder shows more heterogeneous changes than previously recognized. © 1996 John Wiley & Sons, Inc.