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Examination of subsequent reaction products enhanced through parahydrogen‐induced nuclear polarization (PHIP)
Author(s) -
Koch Andreas,
Bargon Joachim
Publication year - 2000
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(200003)38:3<216::aid-mrc635>3.0.co;2-b
Subject(s) - spin isomers of hydrogen , chemistry , dimethyl acetylenedicarboxylate , polarization (electrochemistry) , photochemistry , induced polarization , nuclear magnetic resonance spectroscopy , hyperpolarization (physics) , organic chemistry , hydrogen , catalysis , engineering , cycloaddition , electrical engineering , electrical resistivity and conductivity
Homogeneous hydrogenation with parahydrogen yields strong nuclear spin polarization in the 1 H NMR spectra of the reaction products. This polarization can be transferred to subsequent reaction products and detected by in situ 1 H NMR spectroscopy. As a typical example, the hydrogenation of 1‐phenylpropyne with parahydrogen generates the spin‐polarized molecule 1‐phenylpropene. Upon bromination of this product, its polarization is transferred to the reaction product 1,2‐dibromo‐1‐phenylpropane. As a second example, polarization was observed in the addition product of DBr to spin‐polarized dimethyl maleate which is generated from dimethyl acetylenedicarboxylate by addition of parahydrogen. Copyright © 2000 John Wiley & Sons, Ltd.