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Doubling the sensitivity of natural abundance 13 C– 13 C INADEQUATE with off‐resonance compensation
Author(s) -
Bunkenborg Jakob,
Nielsen Niels Chr.,
Sørensen Ole Winneche
Publication year - 2000
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(200001)38:1<58::aid-mrc611>3.0.co;2-t
Subject(s) - sensitivity (control systems) , chemistry , pulse sequence , resonance (particle physics) , pulse (music) , sequence (biology) , nuclear magnetic resonance , compensation (psychology) , analytical chemistry (journal) , optics , atomic physics , physics , environmental chemistry , electronic engineering , engineering , psychology , biochemistry , detector , psychoanalysis
The INADEQUATE CR experiment about doubles the sensitivity of the original INADEQUATE experiment but it still suffers from severely deteriorated performance in the presence of large off‐resonance effects. In fact, this limitation is exacerbated in INADEQUATE CR because of a more complex pulse sequence. This paper describes the application to INADEQUATE CR of a general scheme developed by Levitt to compensate an entire pulse sequence for pulse imperfections such as off‐resonance effects. By incorporation of this scheme into both INADEQUATE and INADEQUATE CR, it is shown that the doubled sensitivity of the latter is retained for camphor (covering about 200 ppm) on a 500 MHz NMR spectrometer. Copyright © 2000 John Wiley & Sons, Ltd.