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Structures of two novel isomeric triterpenoid saponins from Anthocephalus cadamba
Author(s) -
Sahu Niranjan P.,
Koike Kazuo,
Jia Zhonghua,
Achari Basudeb,
Banerjee Sukdeb,
Nikaido Tamotsu
Publication year - 1999
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199911)37:11<837::aid-mrc567>3.0.co;2-y
Subject(s) - chemistry , aglycone , triterpenoid , stereochemistry , bark (sound) , molecular mechanics , molecule , triterpenoid saponin , two dimensional nuclear magnetic resonance spectroscopy , saponin , organic chemistry , glycoside , medicine , physics , alternative medicine , pathology , acoustics
Two novel triterpenoid saponins, phelasin A ( 1 ) and phelasin B ( 2 ), were isolated from the bark of Anthocephalus cadamba (Roxb) Miq. The structures were established by one‐ and two‐dimensional 1 H and 13 C NMR spectroscopy. The aglycone of 1 , phelasingenin ( 3 ), is a new compound characterized as 3β‐hydroxy‐olean‐18‐ene‐27,28‐dioic acid. Molecular mechanics and molecular dynamics studies carried out on 3 showed the preferred conformation adopted by the molecule. Copyright © 1999 John Wiley & Sons, Ltd.