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Distinguishing diastereomeric organic compounds based on the concerted use of 3 J (C,H) and 3 J (N,H) values
Author(s) -
Gröger Stefan,
Josey John A.,
Poppe Leszek
Publication year - 1999
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199910)37:10<748::aid-mrc541>3.0.co;2-m
Subject(s) - diastereomer , chemistry , heteronuclear molecule , coupling constant , interpretation (philosophy) , computational chemistry , stereochemistry , nuclear magnetic resonance spectroscopy , quantum mechanics , physics , computer science , programming language
The relative stereochemistry of the two acyclic carbons separated by a single bond was determined from three‐bond homo‐ and heteronuclear coupling constants. The analysis of data was based on a purely qualitative interpretation of the Karplus relationships. The methodology presented could resolve acyclic diastereoisomers if adequate sets of three‐bond coupling constants can be measured. Copyright © 1999 John Wiley & Sons, Ltd.