Premium
Characterization of biguanides by 15 N NMR spectroscopy
Author(s) -
Clement B.,
Girreser U.
Publication year - 1999
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199909)37:9<662::aid-mrc518>3.0.co;2-d
Subject(s) - chemistry , nuclear magnetic resonance spectroscopy , characterization (materials science) , spectroscopy , nuclear magnetic resonance , stereochemistry , nanotechnology , physics , quantum mechanics , materials science
The monoprotonated biguanides phenformin hydrochloride, buformin hydrochloride and metformin hydrochloride were investigated by 15 N NMR spectroscopy. The structure of all hydrochlorides is best described by a 1,3‐diazabutadienic skeleton with three amino groups and its corresponding mesomeric forms. There is no evidence for the presence of other tautomeric forms in solution. Copyright © 1999 John Wiley & Sons, Ltd.