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Elucidation of the conformations and absolute configurations of enantiomerically pure tetralin derivatives
Author(s) -
Tóth Gábor,
Simon András,
Linker Torsten,
Rebien Frank,
Kraus Jürgen,
Bringmann Gerhard
Publication year - 1999
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199901)37:1<53::aid-mrc415>3.0.co;2-e
Subject(s) - tetralin , chemistry , absolute configuration , enantioselective synthesis , absolute (philosophy) , stereochemistry , optically active , computational chemistry , organic chemistry , catalysis , philosophy , epistemology
The enantioselective epoxidation of1,2‐dihydronaphthalenes (2) afforded opticallyactive tetralin derivatives (3 and 4). The relativeconfigurations and conformational behavior of all products wereelucidated by detailed one‐ and two‐dimensional 1 H and 13 C NMR methods. The last requiredstereochemical information, the absolute configuration of 4, attainedthrough comparison of experimental and calculated CD spectra. © 1999 John Wiley & Sons, Ltd.