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Application of a selective HSQC experiment to measure interglycosidic heteronuclear long‐range coupling constants in cyclodextrins
Author(s) -
Forgo Peter,
D'Souza Valerian T.
Publication year - 1999
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199901)37:1<48::aid-mrc414>3.0.co;2-3
Subject(s) - heteronuclear molecule , chemistry , heteronuclear single quantum coherence spectroscopy , dihedral angle , coupling constant , cyclodextrin , range (aeronautics) , coupling (piping) , analytical chemistry (journal) , computational chemistry , two dimensional nuclear magnetic resonance spectroscopy , molecule , stereochemistry , organic chemistry , hydrogen bond , mechanical engineering , engineering , physics , materials science , particle physics , composite material
A selective one‐dimensional HSQC experiment wasused to obtain heteronuclear long‐range coupling constants fornative and chemically modified cyclodextrins(3,6‐anhydro‐β‐cyclodextrin) anda non‐covalent complex of α‐cyclodextrin with p ‐nitrophenol. Selective excitation was performed onC‐4 in the α‐glucose units using DANTE hard pulsetrains. The measured heteronuclear long‐range couplingconstants have similar values for all natural cyclodextrins. The highvalue of these coupling constants indicates that the low dihedralangle between H‐1 and C‐4 found in the solid state isretained in solution. Chemical modification or complex formation,however, decreases the coupling constant by increasing the dihedralangle between these nuclei. © 1999 John Wiley & Sons, Ltd.