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Efficient magnetic resonance imaging methods for automated quantitation of magnetic resonance parameters from multiple samples
Author(s) -
Evans Stephen D.,
Nott Kevin P.,
Kshirsagar Ashwini,
Hall Laurance D.
Publication year - 1997
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199712)35:13<s76::aid-omr215>3.0.co;2-r
Subject(s) - homogeneity (statistics) , magnet , magnetic resonance imaging , chemistry , nuclear magnetic resonance , spin echo , magnetic field , resonance (particle physics) , analytical chemistry (journal) , physics , chromatography , atomic physics , statistics , medicine , mathematics , quantum mechanics , radiology
Magnetic resonance imaging methods have been developed which simultaneously measure the bulk magnetic resonance parameters of many samples contained in stacks of multi‐well sample plates using either a 2.35 T, 31 cm or a 2 T, 100 cm horizontal bore magnet each with a quadrature ‘birdcage’ resonator. Computerized automatic edge detection software detects the position of each well within the first spin‐echo image which can then determine the mean magnetic resonance parameters of the sample in each well. An example is given of the automated quantitation of T 1 , T 2 and M 0 values for 2% (w/v) agar gel in four plates each with 30 wells per plate (120 samples in total). It was found that the maximum number of samples that can be analysed is limited by the homogeneity of the probe B 1 field and the B 0 field of the magnet. The applicability of this technology for future applications is discussed. © 1977 John Wiley & Sons, Ltd.