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Comparison of 13 C Resolution and Sensitivity of HSQC and HMQC Sequences and Application of HSQC‐Based Sequences to the Total 1 H and 13 C Spectral Assignment of Clionasterol
Author(s) -
Reynolds William F.,
McLean Stewart,
Tay LiLin,
Yu Margaret,
Enriquez Raul G.,
Estwick Dionne M.,
Pascoe Keith O.
Publication year - 1997
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199707)35:7<455::aid-omr116>3.0.co;2-6
Subject(s) - heteronuclear single quantum coherence spectroscopy , chemistry , multiplet , resolution (logic) , sensitivity (control systems) , spectral line , nuclear magnetic resonance , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , physics , artificial intelligence , electronic engineering , computer science , engineering , astronomy
It is demonstrated that HSQC gives considerably better 13 C resolution and sensitivity than HMQC for CH 2 groups of natural products, particularly when combined with linear prediction. Similarly, coupled HSQC spectra provide a useful method for the determination of 1 H multiplet structure and consequent assignment of individual CH 2 protons as axial or equatorial in fused cyclohexane rings. These and related techniques are used to assign 1 H and 13 C spectra of the marine sterol clionasterol. © 1997 John Wiley & Sons, Ltd.