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Hemisynthesis from Chaetoglobosin M. I—Obtention of Two New Chaetoglobosins by Intramolecular Michael Reaction Under Mild Basic Conditions
Author(s) -
Burlot L.,
Cherton J.C.,
Convert O.,
Larpent C.,
Dennetiere B.,
Dardoize F.
Publication year - 1996
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199607)34:7<538::aid-omr920>3.0.co;2-u
Subject(s) - chemistry , intramolecular force , epoxide , stereochemistry , michael reaction , proton nmr , combinatorial chemistry , organic chemistry , catalysis
Under mild basic conditions, Chaetoglobosin M leads to the formation of two new bridged chaetoglobosins with preservation of the epoxide function. The structures of these new toxins are proposed on the basis of high‐resolution MS and NMR data and supported by molecular modelling.