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Pulsed Field Gradient ‘Inverse’ HOESY Applied to the Isotope Pairs 1 H, 31 P and 1 H, 7 Li*
Author(s) -
Bauer Walter
Publication year - 1996
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/(sici)1097-458x(199607)34:7<532::aid-omr910>3.0.co;2-c
Subject(s) - chemistry , heteronuclear molecule , inverse , nuclear overhauser effect , pulsed field gradient , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , nuclear magnetic resonance , chromatography , stereochemistry , geometry , mathematics , organic chemistry , molecule , physics
For many heteronuclei, inverse ( 1 H detected) heteronuclear Overhauser effect spectroscopy (HOESY) should be superior in theory over heteronucleus detected HOESY. In practice, strong t 1 noise artifacts completely cancel the benefits of inverse HOESY. However, pulsed field gradient (PFG)‐enhanced inverse HOESY yields 2D spectra without any t 1 noise, consisting only of genuine cross peaks. The applicability of the method is demonstrated for thymolphthalein monophosphate hydrate using 31 P, 1 H PFG‐HOESY and for n ‐butyllithium using 7 Li, 1 H PFG‐HOESY. In addition to the absence of t 1 noise, the merit of PFG‐inverse HOESY is improved digital resolution in the usually crowded 1 H domain.