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Raman microspectroscopy of the brain tissues in the substantia nigra and MPTP‐induced Parkinson's disease
Author(s) -
Ong C. W.,
Shen Z. X.,
He Y.,
Lee T.,
Tang S. H.
Publication year - 1999
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/(sici)1097-4555(199902)30:2<91::aid-jrs351>3.0.co;2-h
Subject(s) - substantia nigra , raman spectroscopy , white matter , parkinson's disease , chemistry , mptp , neuromelanin , nuclear magnetic resonance , pathology , neuroscience , biophysics , biology , medicine , disease , optics , physics , magnetic resonance imaging , radiology
The substantia nigra of the rostral mid‐brain of a monkeywas studied using Raman microspectroscopy. The white and grey mattercould be clearly distinguished and their relative proportionsevaluated from the Raman peaks in the 3000 cm −1 region. Raman spectra obtained from the substantia nigra for bothtreated and untreated samples showed that the process of staining theneuron nuclei affected the brain cells and the quality of the Ramanspectra from the treated samples was poorer. The brain cells of amonkey suffering from Parkinson's disease was also studied.Raman spectra collected from the control cells and the diseased cellsdid not show a clear difference. Copyright © 1999 John Wiley& Sons, Ltd.