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Vibrational Studies on the Heterobifunctional Cross‐linking Agents N ‐Succinimidyl 3‐(2‐Pyridyldithio)propionate and N ‐Succinimidyl 6‐[3′‐(2‐Pyridyldithio)propionamido]hexanoate and Theoretical Elucidations
Author(s) -
Pal Biswajit,
Bajpai P. K.,
Sengupta Jayati,
Singh Vinod
Publication year - 1997
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/(sici)1097-4555(199705)28:5<323::aid-jrs99>3.0.co;2-9
Subject(s) - propionate , chemistry , raman spectroscopy , ethyl hexanoate , disulfide bond , propionates , torsion (gastropod) , stereochemistry , crystallography , organic chemistry , biochemistry , surgery , ethyl acetate , physics , optics , medicine
Infrared and Raman spectra of the heterobifunctional cross‐linking agents N ‐succinimidyl 3‐(2‐pyridyldithio)propionate (SPDP) and N ‐succinimidyl 6‐[3′‐(2‐pyridyldithio)propionamido]hexanoate (LC‐SPDP) are reported and the observed IR and Raman bands are assigned. A comparison of C–S and S–S stretching modes in these two systems suggests that the geometry in the disulfide region is different and LC‐SPDP has less torsion. These findings are also supported by semi‐empirical MNDO calculations. This study provides a basis for understanding why the bioefficacy of the conjugates, modified through LC‐SPDP, is greater. © 1997 by John Wiley & Sons, Ltd.