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Ephrins stimulate or inhibit neurite outgrowth and survival as a function of neuronal cell type
Author(s) -
Gao PanPan,
Sun ChunHua,
Zhou XiaoFeng,
DiCiccoBloom Emanuel,
Zhou Renping
Publication year - 2000
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(20000515)60:4<427::aid-jnr1>3.0.co;2-d
Subject(s) - ephrin , erythropoietin producing hepatocellular (eph) receptor , neurite , axon guidance , neuroscience , biology , olfactory bulb , receptor , receptor tyrosine kinase , axon , microbiology and biotechnology , central nervous system , signal transduction , genetics , in vitro
The Eph family of tyrosine kinase receptors and ligands play key roles in cell segregation and axon targeting in the developing nervous system. Interactions between the ligands and receptors cause repulsion or degeneration of receptor‐positive axons from several brain regions including the retina, hippocampus, thalamus, and midbrain dopaminergic system. We extend these previous observations by showing that three A‐ephrins also negatively regulate the growth of neurites from striatal and olfactory neurons. In addition to negative effects, however, we also report a trophic activity of the A‐ephrins: Ephrin‐A2 and A5 promote survival and neurite outgrowth of sympathetic neurons. These observations provide support to the notion that ephrins may function as either negative or positive signals in the developing nervous system. J. Neurosci. Res. 60:427–436, 2000 © 2000 Wiley‐Liss, Inc.