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Does ceramide play a role in neural cell apoptosis?
Author(s) -
Goswami Raja,
Dawson Glyn
Publication year - 2000
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(20000415)60:2<141::aid-jnr2>3.0.co;2-5
Subject(s) - ceramide , apoptosis , microbiology and biotechnology , lipid signaling , programmed cell death , cell growth , cell , second messenger system , cell cycle , cell cycle checkpoint , receptor , biology , signal transduction , biochemistry
Ceramide is a lipid second messenger, that is generated in response to stimulation of the cell death pathways by a number of ligands binding to surface receptors, growth factor withdrawal, treatment with chemotherapeutic agents, or high doses of ionizing radiation or oxidizing agents. Depending on the target cell, ceramide induces diverse biological responses including apoptosis, cell‐cycle arrest, differentiation, and also proliferation. In this review we consider the evidence for its role in apoptosis in cells of the nervous system. J. Neurosci. Res. 60:141–149, 2000 © 2000 Wiley‐Liss, Inc.