Premium
Involvement of OSP/claudin‐11 in oligodendrocyte membrane interactions: Role in biology and disease
Author(s) -
Bronstein Jeff M.,
TiwariWoodruff Seema,
Buznikov Alexei G.,
Stevens David B.
Publication year - 2000
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(20000315)59:6<706::aid-jnr2>3.0.co;2-d
Subject(s) - claudin , myelin , transmembrane protein , oligodendrocyte , microbiology and biotechnology , biology , tight junction , demyelinating disease , extracellular , membrane protein , extracellular matrix , myelin sheath , neuroscience , immunology , central nervous system , membrane , receptor , genetics
Abstract Oligodendrocyte‐specific protein (OSP/claudin‐11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin‐11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin‐11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin‐11 as an autoantigen in the development of autoimmune demyelinating disease. J. Neurosci. Res. 59:706–711, 2000 © 2000 Wiley‐Liss, Inc.