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Understanding CNS remyelination: Clues from developmental and regeneration biology
Author(s) -
Franklin R.J.M.,
Hinks G.L.
Publication year - 1999
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19991015)58:2<207::aid-jnr1>3.0.co;2-1
Subject(s) - remyelination , regeneration (biology) , neuroscience , biology , regenerative process , cognitive science , process (computing) , psychology , central nervous system , computer science , myelin , microbiology and biotechnology , operating system
A guiding principle in remyelination research has been to seek clues to its nature in developmental studies on myelination. This “recapitulation hypothesis” argues that the regenerative response involves rerunning much the same programme as occurs during the developmental process. Here we examine the extent to which current evidence supports this hypothesis and whether this is a useful conceptual framework within which to study remyelination and suggest that an equally fruitful approach is to look to regenerative processes in other tissues. J. Neurosci. Res. 58:207–213, 1999. © 1999 Wiley‐Liss, Inc.