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Effect of neutron‐gamma radiation on dopamine and serotonin metabolism in the rat brain: A regional analysis
Author(s) -
Foulon Olivier,
Lalouette Frédéric,
Lambert Fabrice,
Martin Serge,
Fatôme Marc,
Martin Christine
Publication year - 1999
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19990315)55:6<770::aid-jnr11>3.0.co;2-a
Subject(s) - dopamine , striatum , serotonin , metabolite , chemistry , medicine , substantia nigra , endocrinology , metabolism , biology , dopaminergic , receptor
The concentrations of dopamine (DA) and its metabolites and the levels of 5‐hydroxyindoleacetic acid (5‐HIAA), the metabolite of serotonin, were determined in discrete cerebral areas of rats 3 hr after (neutron‐gamma) irradiation at 4 and 7 Gy. After the 7 Gy irradiation, no significant effect was observed. After the 4 Gy exposure, the most marked difference between irradiated and control rats was in the levels of DA and its metabolites in the striatum. We observed a decrease of DA, HVA, and DOPAC levels in the striatum and an opposite pattern in the substantia nigra. Whatever the brain area observed, an increase of 5‐HIAA levels was noted. J. Neurosci. Res. 55:770–775, 1999. © 1999 Wiley‐Liss, Inc.