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Expression of doublecortin correlates with neuronal migration and pattern formation in diverse regions of the developing chick brain
Author(s) -
Hannan Anthony J.,
Henke Robert C.,
Seeto Gregory S.,
CapesDavis Amanda,
Dunn Joanne,
Jeffrey Peter L.
Publication year - 1999
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19990301)55:5<650::aid-jnr12>3.0.co;2-s
Subject(s) - doublecortin , lissencephaly , biology , forebrain , neuroscience , corticogenesis , glutamatergic , human brain , neurogenesis , cerebellum , gene , microbiology and biotechnology , dentate gyrus , genetics , hippocampus , central nervous system , receptor , glutamate receptor , embryonic stem cell
Abstract The development of functional layers in the brain involves spatially and temporally regulated gene expression. Through cDNA library screening, we have identified genes that are expressed in a neural‐specific manner during brain development. Sequencing and expression data indicate that one of the clones, 18C15, is the chick homologue of doublecortin, a human X‐linked gene found to be mutated in subcortical laminar heterotopia (double cortex syndrome) and lissencephaly. The 18C15 mRNA contains multiple motifs that are known to regulate mRNA stability in response to inductive signals, and these motifs are conserved between the chick and human sequences. Doublecortin is found to be expressed at peak levels during early development of the cerebellum and forebrain, and is expressed in other regions including the tectum, spinal cord, and dorsal root ganglia. This study demonstrates both spatial and temporal regulation of doublecortin expression in the chick, which is associated with early events in brain development, including neuronal migration. J. Neurosci. Res. 55:650–657, 1999. © 1999 Wiley‐Liss, Inc.

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