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Rat model of perinatal hypoxic‐ischemic brain damage
Author(s) -
Vannucci R.C.,
Connor J.R.,
Mauger D.T.,
Palmer C.,
Smith M.B.,
Towfighi J.,
Vannucci S.J.
Publication year - 1999
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19990115)55:2<158::aid-jnr3>3.0.co;2-1
Subject(s) - brain damage , neuroscience , hypoxia (environmental) , medicine , psychology , chemistry , oxygen , organic chemistry
To gain insights into the pathogenesis and management of perinatal hypoxic‐ischemic brain damage, the authors have used an immature rat model which they developed many years ago. The model entails ligation of one common carotid artery followed thereafter by systemic hypoxia. The insult produces permanent hypoxic‐ischemic brain damage limited to the cerebral hemisphere ipsilateral to the carotid artery occlusion. The mini‐review describes recently accomplished research pertaining to the use of the immature rat model, specifically, investigations involving energy metabolism, glucose transporter proteins, free radical injury, and seizures superimposed upon cerebral hypoxia‐ischemia. Future research will focus on molecular mechanisms of neuronal injury with a continuing focus on therapeutic strategies to prevent or minimize hypoxic‐ischemic brain damage. J. Neurosci. Res. 55:158–163, 1999. © 1999 Wiley‐Liss, Inc.