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Role of the CNS microvascular pericyte in the blood‐brain barrier
Author(s) -
Balabanov Roumen,
DoreDuffy Paula
Publication year - 1998
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19980915)53:6<637::aid-jnr1>3.0.co;2-6
Subject(s) - blood–brain barrier , pericyte , neuroscience , angiogenesis , central nervous system , macrophage , pathogenesis , biology , medicine , endothelial stem cell , immunology , cancer research , biochemistry , in vitro
Pericytes are a very important cellular constituent of the blood‐brain barrier. They play a regulatory role in brain angiogenesis, endothelial cell tight junction formation, blood‐brain barrier differentiation, as well as contribute to the microvascular vasodynamic capacity and structural stability. Central nervous system pericytes express macrophage functions and are actively involved in the neuroimmune network operating at the blood‐brain barrier. They exhibit unique functional characteristics critical for the pathogenesis of a number of cerebrovascular, neurodegenerative, and neuroimmune diseases. J. Neurosci. Res. 53:637–644, 1998. © 1998 Wiley‐Liss, Inc.