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Redefining the lipophilin family of proteolipid proteins
Author(s) -
Gow Alexander
Publication year - 1997
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19971201)50:5<659::aid-jnr3>3.0.co;2-g
Subject(s) - proteolipid protein 1 , myelinogenesis , myelin proteolipid protein , integral membrane protein , myelin , membrane protein , biology , protein family , gene , genetics , oligodendrocyte , microbiology and biotechnology , central nervous system , myelin basic protein , neuroscience , membrane
The past few years have seen a dramatic increase in our understanding, in molecular terms, of the involvement of the central nervous system proteolipid protein in myelinogenesis and X‐linked genetic diseases. In addition, we have expanded our knowledge of the proteins that have been recruited into the vertebrate myelin membrane over the past 400 million years with the molecular cloning of several cDNAs encoding proteins which are homologous to the proteolipid protein gene. In searching for a name to distinguish these proteins from other “proteolipid” proteins of nonneural origin I propose that we resurrect the term “lipophilins” which describes a small family of unusually hydrophobic integral membrane proteins exhibiting identical topologies and similar physical properties. Two subgroups are distinguishable among the lipophilins based on the patterns of expression during development and the presence or absence of a small motif that is exposed to the extracellular space. J. Neurosci. Res. 50:659–664, 1997. © 1997 Wiley‐Liss, Inc.