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Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation
Author(s) -
Yeo Tracy T.,
Yang Tao,
Massa Stephen M.,
Zhang Julie S.,
Honkaniemi Jari,
Butcher Larry L.,
Longo Frank M.
Publication year - 1997
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19970201)47:3<348::aid-jnr13>3.0.co;2-y
Subject(s) - basal forebrain , cholinergic , biology , neuroscience , cholinergic neuron , dentate gyrus , hippocampal formation , forebrain , protein tyrosine phosphatase , receptor , neurite , central nervous system , genetics , in vitro
A role in neural development for protein tyrosine phosphatase (PTPase) receptors has been suggested by the finding of aberrant neurite outgrowth in Drosophila mutants lacking functional leukocyte common antigen‐related (LAR) PTPase receptors; however, PTPase functions in the mammalian nervous system remain to be established. In transgenic mice containing a gene trap in the LAR gene, only trace expression of full‐length LAR transcripts was found. In these mice, the size of basal forebrain cholinergic neurons was significantly reduced and cholinergic innervation of the dentate gyrus was markedly decreased. These findings constitute the first demonstration of an aberrant neuronal phenotype in a mammalian PTPase mutant and support the hypothesis that LAR‐type PTPase receptors function to establish and/or maintain neuronal networks. J. Neurosci. Res. 47:348–360, 1997. © 1997 Wiley‐Liss, Inc.