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Analysis of T cell receptor β chains in the rat: I. Allelic polymorphism of Vβ8.2 is not a predisposing genetic factor in susceptibility to experimental allergic encephalomyelitis
Author(s) -
Gold D.P.,
Schroder K.,
Mueller D.B.,
Wilson D.B.
Publication year - 1996
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19960915)45:6<700::aid-jnr6>3.0.co;2-c
Subject(s) - encephalomyelitis , t cell receptor , allele , gene , biology , immunology , genetic predisposition , microbiology and biotechnology , t cell , receptor , genetics , immune system , multiple sclerosis
Previous studies of experimental allergic encephalomyelitis (EAE) in the LER rat have suggested that amino acid differences present in the LER TCR Vβ8.2 chain may be associated with disease resistance. We report here that LEW rats bred to express a Vβ8.2 gene from DA rats, identical to that found in LER, are susceptible to EAE induction. Furthermore, T cells infiltrating the spinal cord of diseased animals primarily utilized Vβ8.2 and the associated AspSer CDR3 motif, typical of TCR Vβ8.2 chains expressed by pathogenic, anti‐MBP responsive T cells in the LEW rat. © 1996 Wiley‐Liss, Inc.