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Effects of glutamic acid and related agents on horizontal cells in a marine teleost retina
Author(s) -
Laufer M.,
Negishi K.,
Salas R.
Publication year - 1996
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19960615)44:6<568::aid-jnr7>3.0.co;2-9
Subject(s) - kainate receptor , kainic acid , retina , synapse , glutamic acid , biology , glutamate receptor , intracellular , aspartic acid , retinal , agonist , excitatory postsynaptic potential , receptor , quisqualic acid , microbiology and biotechnology , amino acid , neuroscience , chemistry , ampa receptor , biophysics , biochemistry
Excitatory amino acids (EAAs) such as glutamic and aspartic acids, considered as the most likely neurotransmitters at the photoreceptor‐horizontal cell synapse of teleost retinas, as well as agonists such as kainic acid and several of their antagonists, were applied to isolated and superfused retinas of the teleost Eugerres plumieri . Intracellular recordings from horizontal cells reveal that EAA receptors are of the kainate‐quisqualate type. There is competitive inhibition between the agonist and anatogonist agents used, and under their combined effect, the synapse under study remains operational, in a functional state, able to modulate the horizontal cell membrane potential upon retinal illumination. © 1996 Wiley‐Liss, Inc.