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Vβ CDR3 motifs associated with BP recognition are enriched in OX‐40 + spinal cord T cells of lewis rats with EAE
Author(s) -
Buenafe A.C.,
Weinberg A.D.,
Culbertson N.E.,
Vandenbark A.A.,
Offner H.
Publication year - 1996
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19960615)44:6<562::aid-jnr6>3.0.co;2-9
Subject(s) - experimental autoimmune encephalomyelitis , antigen , immunology , microbiology and biotechnology , t cell , spinal cord , biology , encephalomyelitis , multiple sclerosis , inflammation , chemistry , immune system , neuroscience
Spinal cord (SC) T cells were isolated at the onset of actively induced experimental autoimmune encephalomyelitis (EAE) and sorted for the presence of the OX‐40 activation marker. Previously, we reported an enhanced bias in Vβ8.2 expression as well as enhanced proliferative responses to basic protein antigens among the OX‐40 + SC T cells. Here we demonstrate that CDR3 motifs associated with EAE are present at a significantly higher frequency in Vβ8.2 sequences of OX‐40 + SC T cells (16/17) compared with those of OX‐40 − SC T cells (5/17). Thus, the OX‐40 antigen may be useful as a marker to isolate and characterize autoantigen‐specific T cells from the site of inflammation in T‐cell‐mediated autoimmune diseases. © 1996 Wiley‐Liss, Inc.