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CaM I mRNA is localized to apical dendrites during postnatal development of neurons in the rat brain
Author(s) -
Berry F.B.,
Brown I.R.
Publication year - 1996
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/(sici)1097-4547(19960301)43:5<565::aid-jnr6>3.0.co;2-g
Subject(s) - hippocampal formation , intracellular , biology , messenger rna , microbiology and biotechnology , calmodulin , neuroscience , gene , genetics , biochemistry , enzyme
In the rat, a single calmodulin (CaM) protein is encoded by three separate genes which produce five different transcripts. The significance of the multiple CaM genes is not known; however, individual CaM transcripts could be targeted to specific intracellular sites. In this report, the cellular distribution of CaM I mRNAs was analyzed in the postnatal rat brain. The 4.0‐kb CaM I transcript was present in neuronal cell bodies and also localized to apical dendritic processes. In cerebral cortical neurons, the 4.0‐kb CaM I mRNA was detected in apical dendrites at postnatal day (PD) 5 to 15. In hippocampal neurons, this CaM message was present in dendritic processes from PD 5 to 20, whereas in Purkinje neurons it was detected in dendrites at PD 15 and 20. The presence of the 4.0‐kb CaM I mRNA in dendrites of the rat brain supports the notion of targeting transcripts derived from the CaM multigene family to discrete intracellular destinations. © 1996 Wiley‐Liss, Inc.