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The impact of primary tumor volume on local control for oropharyngeal squamous cell carcinoma treated with radiotherapy
Author(s) -
Nathu Rakesh M.,
Mancuso Anthony A.,
Zhu Timothy C.,
Mendenhall William M.
Publication year - 2000
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(200001)22:1<1::aid-hed1>3.0.co;2-6
Subject(s) - medicine , radiation therapy , primary tumor , stage (stratigraphy) , chemotherapy , head and neck squamous cell carcinoma , basal cell , induction chemotherapy , head and neck cancer , multivariate analysis , head and neck , nuclear medicine , radiology , oncology , cancer , surgery , metastasis , paleontology , biology
Background A study was needed to determine the effect of primary tumor volume on local control of oropharyngeal carcinoma treated with radiation therapy, with or without induction chemotherapy. Methods Between July 1983 and April 1995, 114 patients with T2–T4 squamous cell carcinoma of the oropharynx were treated for cure with radiation therapy, with or without induction chemotherapy, and had a pretreatment CT scan available for retrospective review. All scans were reviewed by a single radiologist (A. A. M.) to determine the tumor volume of the primary lesion. Volume was measured with a computer digitizer for each CT slice showing the primary lesion. Results A large variation in tumor volume within a given T stage was found. Multivariate analysis demonstrated T stage to be the most significant factor affecting local control. Tumor volume marginally influenced local control ( p = .10). Conclusions Primary tumor volume varies significantly within a given T stage and has a marginal impact on the likelihood of local control after radiotherapy. © 2000 John Wiley & Sons, Inc. Head Neck 22: 1–5, 2000.