Premium
Familial mixed tumors of the parotid gland
Author(s) -
Ahn Min S.,
Hayashi Grant M.,
Hilsinger Raymond L.,
Lalwani Anil K.
Publication year - 1999
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199912)21:8<772::aid-hed14>3.0.co;2-p
Subject(s) - parotid gland , pleomorphic adenoma , mixed tumor , pathology , salivary gland , medicine , neoplasm
Background The most common neoplasm of the parotid gland is the pleomorphic adenoma. The familial occurrence of such tumors arising within the parotid gland is rare, with only 3 previous reports in the literature. Bilateral synchronous pleomorphic adenomas of the parotid gland are also uncommon. We report 2 siblings with pleomorphic adenomas of the parotid gland, 1 of whom had bilateral synchronous mixed tumors. Patients and Methods Chromosomal analysis of tumor cells from the sibling with bilateral adenomas revealed the translocation t(3;12)(p21;q15). Chromosome 12q breakpoints have previously been identified in a wide variety of solid tumors including pleomorphic adenomas of the parotid gland. Conclusions We discuss bilateral mixed tumors, familial parotid tumors, and the potential for a genetic predisposition for the recurrence of such parotid tumors, as suggested by characteristic chromosomal translocations associated with mixed tumors. © 1999 John Wiley & Sons, Inc. Head Neck 21: 772–775, 1999.