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No relationship between proliferative activity and the MACIS prognostic scoring system in papillary thyroid carcinoma
Author(s) -
Leite Katia Ramos Moreira,
de Araujo Vera Cavalcanti,
Rezende Meirelles Maria Ines,
de Lisboa Lopes Costa Antonio,
CamaraLopes Luiz H.
Publication year - 1999
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199910)21:7<602::aid-hed3>3.0.co;2-v
Subject(s) - proliferating cell nuclear antigen , immunostaining , pathology , thyroid carcinoma , immunohistochemistry , staining , thyroid , nucleolus organizer region , carcinoma , ki 67 , medicine , biology , nucleus , psychiatry , nucleolus
Background The MACIS score uses metastasis, age, completeness of resection, local invasion, and tumor size to stratify patients with papillary thyroid carcinoma (PTC) into four groups with different survival. Methods Immunostaining for proliferating cell nuclear antigen (PCNA) was done in 43 cases of PTC. Relationships between proliferative index (percentage of cells that were PCNA positive) and the MACIS parameters were examined. Double staining for PCNA and for silver‐stained nucleolar organizer regions (AgNORs, indicating proliferation) was performed in 10 cases. Results PCNA was detected only in tumor cells. The proliferative index was low (mean, 14.2%; median, 13.0%), did not differ between MACIS groups ( p = 0.56), and showed no association with individual MACIS parameters. PCNA immunostaining correlated with AgNOR staining. The mean AgNOR count was 2.28 in PCNA‐positive cells and 1.85 in PCNA‐negative cells ( p ≤ 0.002). Conclusions PCNA immunostaining indicates proliferative activity in PTC. It is independent of the MACIS score and its parameters. © 1999 John Wiley & Sons, Inc. Head Neck 21: 602–605, 1999.