Premium
Postoperative radiation therapy for primary vs. recurrent squamous cell carcinoma of the head and neck: Results of a comparative analysis
Author(s) -
Regine William F.,
Valentino Joseph,
Sloan David A.,
Patel Pushpa,
Pittard Melissa Q.,
Kenady Daniel E.,
Mohiuddin Mohammed
Publication year - 1999
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199909)21:6<554::aid-hed9>3.0.co;2-2
Subject(s) - medicine , radiation therapy , head and neck , basal cell , head and neck squamous cell carcinoma , oncology , head and neck cancer , surgery
Background There is little literature comparatively evaluating the results of postoperative radiation therapy (RT) for patients with squamous cell carcinoma (SCC) of the head and neck treated for primary versus recurrent disease. Methods Between 1981 and 1993, 174 patients with SCC of the head and neck, 143 with primary and 31 with recurrent disease, were treated with standard postoperative RT. Results Patients treated for primary disease had 5‐year local‐regional control (LRC) and disease‐specific survival (DSS) rates of 69% and 54%, respectively, as compared with 46% and 32%, respectively, for patients treated for recurrent disease ( P = 0.03 and 0.04, respectively). On multivariate analysis, only tumor type (primary vs recurrent) significantly influenced LRC ( P = 0.003) and only primary tumor site (oral cavity vs nonoral cavity) significantly influenced DSS ( P = 0.04). Among the patients treated for recurrent disease, site of recurrence (undissected vs dissected tissue) significantly influenced both LRC and DSS ( P = 0.008 and 0.001, respectively). Conclusions Patients with recurrent SCC of the head and neck do poorly as compared with those with primary disease when treated with standard postoperative RT, particularly when the recurrence is within previously dissected tissue. This patient group should be targeted for alternative treatment strategies. © 1999 John Wiley & Sons, Inc. Head Neck 21: 554–559, 1999.