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National cancer data base report on cancer of the head and neck: Acinic cell carcinoma
Author(s) -
Hoffman Henry T.,
Karnell Lucy Hynds,
Robinson Robert A.,
Pinkston John A.,
Menck Herman R.
Publication year - 1999
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199907)21:4<297::aid-hed2>3.0.co;2-r
Subject(s) - acinic cell carcinoma , medicine , cancer , head and neck cancer , head and neck , radiation therapy , carcinoma , oncology , surgery , mucoepidermoid carcinoma
Background Management of acinic cell carcinoma is based on reports of small numbers of cases accrued over several decades. Methods The National Cancer Data Base (NCDB) identified 1353 cases of acinic cell carcinoma of the head and neck for the years 1985 to 1995. Chi square analyses of selected contingency tables and Wilcoxon regression analyses of selected survival stratifications are presented. Results Five‐year survival was 83.3% (observed) and 91.4% (disease specific). Worse survival was associated with high grade ( p < .0001), age greater or equal to 30 years ( p = .0055), and the presence of metastatic disease ( p < .0001). Conclusions An aggressive subset of acinic cell carcinoma which is characterized by high grade and advanced stage rarely occurs in patients younger than 30 years old. Although better outcome was not statistically demonstrated for combined therapy, surgery with irradiation is the most common management in the United States for cases with regional metastases, high grade, and microscopic positive margins. © 1999 John Wiley & Sons, Inc. Head Neck 21: 297–309, 1999.