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New combined treatment of surgery, radiotherapy, and reconstruction in head and neck rhabdomyosarcoma in children: The amore protocol
Author(s) -
Schouwenburg Paul F.,
Kupperman David,
Bakker Frans P.,
Blank Leo E. C. M.,
de Boer Hans B.,
Voûte Tom A.
Publication year - 1998
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199807)20:4<283::aid-hed1>3.0.co;2-v
Subject(s) - medicine , rhabdomyosarcoma , radiation therapy , surgery , reconstructive surgery , chemotherapy , head and neck , brachytherapy , ablative case , stage (stratigraphy) , sarcoma , paleontology , pathology , biology
Background If no complete remission on chemotherapy is reached in head and neck rhabdomyosarcoma (RMS) in children, adjuvant radiotherapy and/or surgery are indicated. This often causes severe mutilation, and the prognosis is poor. Ablative surgery, moulage technique with afterloading brachytherapy, and reconstructive surgery, called the AMORE protocol, is developed for residual or recurrent disease after chemotherapy. Methods Ablative surgery with preservation of important structures is followed by the embedding of a gutta‐percha mold in the created tissue defect. The wound bed is irradiated with Iridium 192 . Within 1 week, the defect is reconstructed with a muscle transplant. Fifteen children (mean age, 5.7 years) were treated accordingly. Results All patients were discharged within 4 weeks. Eleven patients are tumor‐free, with a mean follow‐up period of 2.8 years. No signs of radiation sequelae were observed. Conclusion The preliminary results of this new, combined treatment are encouraging, if the advanced stage of disease is considered. © 1998 John Wiley & Sons, Inc. Head Neck 20:283–292, 1998.