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Clinically aggressive metastasizing pleomorphic adenoma: Report of two cases
Author(s) -
Klijanienko Jerzy,
ElNaggar Adel K.,
Servois Vincent,
Rodriguez Joseph,
Validire Pierre,
Vielh Philippe
Publication year - 1997
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199710)19:7<629::aid-hed11>3.0.co;2-y
Subject(s) - pleomorphic adenoma , malignancy , medicine , cytology , pathology , histology , radiation therapy , parotid gland , metastasis , salivary gland , radiology , cancer
Background It has been suggested that metastasizing pleomorphic adenomas may represent unrecognized malignancy. Methods The cytologic and clinical characteristics of two metastasizing pleomorphic adenomas diagnosed by fine‐needle sampling are reported. Results Both showed malignant evolution: the primary tumors arose from the palate and the parotid salivary glands, respectively. Metastases occurred simultaneously with local recurrence in the first patient and after a second local recurrence in the second patient. Both patients were treated by surgery and radiotherapy but died of disseminated disease 8 and 4 years after initial diagnosis. No histologic evidence of malignancy was observed on cytology smears or histology sections in either case. Conclusion Clinically, our cases support the hypothesis that metastasizing pleomorphic adenomas represent unrecognized malignancy, because the biologic course of two tumors led to unequivocally lethal outcome. © 1997 John Wiley & Sons, Inc. Head Neck 19 : 629–633, 1997.