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Granulocyte colony stimulating factor‐producing tongue carcinoma
Author(s) -
Horii Arata,
Shimamura Kazuo,
Honjo Yuichiro,
Mitani Kenji,
Miki Tomohiro,
Takashima Shodayu,
Yoshida JunIchi
Publication year - 1997
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199707)19:4<351::aid-hed15>3.0.co;2-c
Subject(s) - leukocytosis , leukemoid reaction , granulocyte colony stimulating factor , immunohistochemistry , pathology , tongue , carcinoma , granulocyte , medicine , white blood cell , chemotherapy
Background Leukocytosis without infection in patients with malignancies is known as the leukemoid reaction. The mechanisms involved in this phenomenon remain uncertain. Methods We describe the clinical, biochemical and immunohistochemical findings in a patient with recurrent tongue carcinoma accompanied by marked leukocytosis as high as 96200/mm 3 . Results The serum granulocyte colony stimulating factor (G‐CSF) concentration was increased to 204 (normal: < 30) pg/ml, which paralleled to the elevation of white blood cell (WBC) count and the tumor growth. The G‐CSF content of the tumor tissue was also elevated (131 pg/mg protein) compared to that in control patients (6.63±2.63 pg/mg protein). Production of G‐CSF from the tumor was evidenced by immunohistochemical staining with monoclonal antibody against human recombinant G‐CSF. Conclusions We suggest that the G‐CSF production of the tumor participates in the mechanisms of the leukemoid reaction. © 1997 John Wiley & Sons, Inc. Head Neck 19 : 251–356, 1997.