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Sphenoid sinus localization of multiple myeloma revealing evolution from benign gammopathy
Author(s) -
Bachmeyer Claude,
Levy Vincent,
Carteret Martine,
Laccourreye Olivier,
Danel Claire,
Tourneau Agnes Le,
Zittoun Robert,
Grateau Gilles
Publication year - 1997
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199707)19:4<347::aid-hed14>3.0.co;2-6
Subject(s) - plasma cell neoplasm , medicine , multiple myeloma , plasma cell , plasmacytoma , sinus (botany) , gammopathy , pathology , monoclonal gammopathy of undetermined significance , magnetic resonance imaging , plasma cell myeloma , head and neck , radiology , bone marrow , monoclonal , monoclonal antibody , antibody , surgery , botany , immunology , biology , genus
Background Plasma‐cell neoplasms of the head and neck include extramedullary plasmacytoma and solitary plasmocytoma of bone or may represent a local manifestation of multiple myeloma. Involvement of sphenoid sinus has been rarely reported in multiple myeloma. Methods We present the case of a 77‐year‐old man with a 3‐year‐history of benign monoclonal IgG‐lambda gammopathy who developed left sixth‐nerve palsy and malaise. Results Computed tomography scan and magnetic resonance imaging scan disclosed a large soft‐tissue mass of the sphenoid sinus with bone destruction. Sphenoid sinus biopsy revealed an IgG monoclonal plasma cell neoplasm. Diagnosis of multiple myeloma stage IA was then established. Conclusions Diagnosis of plasma‐cell neoplasm should be considered in sphenoid sinus tumors and depends upon histologic examination. This case enlightens the relationships between monoclonal benign gammopathy and plasma‐cell neoplasms of the head and neck which constitute a continuum of B‐cell lymphoproliferative disorders. © 1997 John Wiley & Sons, Inc. Head Neck 19 : 347–350, 1997.